Selcuk Gulmez; Aziz Serkan Senger; Orhan Uzun; Sinan Omeroglu; Cem Batuhan Ofluoglu; Ayhan Oz; Erdal Polat; Ugur Duman
Volume 24, Issue 3 , 2022
Abstract
Background: Gastric cancer is the fifth most frequent cancer worldwide and the third major cause of cancer-related fatalities
Objectives: The current study aims to investigate whether there is a relationship between tumor location and various prognostic factors in patients who underwent curative resection ...
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Background: Gastric cancer is the fifth most frequent cancer worldwide and the third major cause of cancer-related fatalities
Objectives: The current study aims to investigate whether there is a relationship between tumor location and various prognostic factors in patients who underwent curative resection for gastric cancer.
Methods: A total of 293 patients who underwent curative surgical resection for gastric cancer were analysed retrospectively. Siewert type II and III tumours were defined as proximal gastric cancer (PGC). More distally located tumours were defined as distal gastric cancer (DGC). Siewert type I tumours were excluded.
Results: Out of 293 patients, 78 were diagnosed with PGC and 215 had DGC. There was a significant relationship between preoperative/postoperative chemotherapy administration, gastrectomy type, presence of lymphatic metastasis, Tumour-Node-Metastasis stage, and tumour localization (P < 0.05). There was no significant difference between PGC and DGC in terms of length of hospital stay (P = 0.137). Five-year survival rates for PGC and DGC were 48.4% and 45.8%, respectively (P = 0.863). pT stage, preoperative and postoperative chemotherapy were determined as independent risk factors (P < 0.05). The location of the tumour and the type of surgical resection did not affect the prognosis (P > 0.05).
Conclusion: Tumour localization is not a prognostic factor in gastric cancer. When safe surgical margins were provided in DGC, total gastrectomy for DGC had no effect on the survival rate.
orhan uzun; Aziz serkan SENGER; Cem Batuhan OFLUOGLU; Ayhan OZ; Sinan OMEROGLU; Erdal POLAT; Mustafa DUMAN
Volume 22, Issue 9 , 2020
Abstract
objective: The present study aims to evaluate the incidence of signet ring cell (SRC) histology in patients with gastric cancer and its prognostic significance on the disease stage.
Methods: Between November 2006 and September 2019, 309 patients were reviewed retrospectively in Kartal Ko?uyolu ...
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objective: The present study aims to evaluate the incidence of signet ring cell (SRC) histology in patients with gastric cancer and its prognostic significance on the disease stage.
Methods: Between November 2006 and September 2019, 309 patients were reviewed retrospectively in Kartal Ko?uyolu High Specialization Training and Research Hospital Gastroenterology Surgery clinic in Turkey and the clinicopathological features and survival status were examined in the presence of ring cell histology.
Results: Of the patients, 71.4% had gastric cancer with a non-SRC histology and 28.6% had an SRC histology. The presence of an SRC histology was found to be associated with young age (p=0.007), advanced depth of wall invasion (p=0.001), number of positive lymph nodes (p=0.022) and presence of vascular invasion (p=0.044). The presence of an SRC histology was associated with good prognosis in patients with stage I gastric cancer (p=0.045), but with poor prognosis in patients with stage III disease (p=0.034). The study found no significant association between stage II disease and overall survival.
Conclusions: The present study found survival to be associated with good prognosis in stage I, and poor prognosis in stage III among patients with gastric cancer with SRC histology. No prognostic significance could be established for overall survival.
